Aluminum Oxide Review:
Link: https://toxnet.nlm.nih.gov/cgi-bin/sis/search/a?dbs+hsdb:@term+@DOCNO+506
https://www.nj.gov/health/eoh/rtkweb/documents/fs/2891.pdf
https://pubchem.ncbi.nlm.nih.gov/compound/Aluminum-oxide
https://druginfo.nlm.nih.gov/drugportal/rn/1344-28-1
The text is big, but worth reading!
Here is a summary
for more information, search the NLM HSDB database.
Human Health Effects:
TOXICOLOGY: Aluminum inhibits bone remodeling, causing osteomalacia. It is believed to inhibit erythropoiesis, causing anemia
REPRODUCTIVE HAZARDS
A) Aluminum in drinking water has been linked to central nervous system birth defects. Some aluminum compounds have proven teratogenic in laboratory animals; however, overall, aluminum is not considered teratogenic.
HUMAN OVERVIEW
A) Although aluminum and its compounds have shown little evidence of carcinogenicity in humans, exposure to other substances involved in the production of aluminum has been linked to carcinogenicity.
ANIMAL OVERVIEW
A) Aluminum has caused cancer, leukemia and lymphoma in laboratory animals.
GENOTOXICITY
A) Aluminum binds to DNA and relaxes its supercoiled structure. It also has been linked to increased sister chromatid exchange, mutagenesis and increased DNA synthesis.
