Evaluation of Nephrotoxicity in Oreochromis niloticus After Exposure to Aluminum Oxide Nanoparticles: Exposure and Recovery Study
Link: https://pubmed.ncbi.nlm.nih.gov/34331072/
2022 Feb;108(2):292-299. doi: 10.1007/s00128-021-03335-z. Epub 2021 Jul 30.
Amr Adel Abdel-Khalek 1, Saleh Al-Quraishy 2, Rewaida Abdel-Gaber 2
Affiliations PMID: 34331072 DOI: 10.1007/s00128-021-03335-z
Abstract
Nephrotoxic impacts of Al2O3 nanoparticles (NPs) were studied in Oreochromis niloticus after seven days of exposure and fifteen days of recovery periods. Fish were classified as group I (dechlorinated water); group II (2 mg/L Al2O3NPs); group III (4 mg/L Al2O3NPs); group IV (8 mg/L Al2O3NPs). Blood creatinine and uric acid levels showed marked increases in groups III and IV. A dose-dependent disturbance in renal antioxidant components was recorded as indicated by elevated catalase, superoxide dismutase, thiobarbituric acid reactive substances levels, and decreased glutathione reduced concentration. Renal histopathology was recorded with the highest % of appearance in group IV. A reduction in renal Al content, kidney function biomarkers (excepting group IV), and enhanced antioxidant status were observed after applying a recovery strategy. Several structural damages were identified following the recovery period, but the alteration frequencies indicated regressive histopathological changes. The Al2O3NPs-induced nephrotoxicity can be reduced after applying a suitable recovery period.
Keywords: Histopathological alterations; Kidney functions; Nephrotoxicity; O. niloticus; Oxidative stress biomarkers.
OBS: Blood levels of creatinine and uric acid showed marked increases after seven days of exposure to aluminum oxide.
Don't forget that there are implant systems that use aluminum oxide.
OBS: Os níveis sanguíneos de creatinina e ácido úrico mostraram aumentos acentuados após sete dias de exposição ao óxido de alumínio.
Não esqueça que existem sistemas de implantes que usam óxido de alumínio.
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